diff --git a/setup.cfg b/setup.cfg
index a4b7b693..c2208da6 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -50,7 +50,7 @@ install_requires =
     img2pdf>=0.3.0,<0.5  # pure Python
     packaging>=20
     pdfminer.six!=20200720,>=20191110,<=20211012
-    pikepdf>=4.0.0
+    pikepdf>=4.0.0,!=5.0.0
     pluggy>=0.13.0,<2
     reportlab>=3.5.66
     tqdm>=4